… this short-range NHEJ complex requires DNA ligase IV (Lig4), … Lig4 complex promotes the
activity of DNA ligase III (Lig3). … of the ligase complex (but not its ligase activity) is sufficient to …

… interactions of the NHEJ-specific DNA Ligase IV (Lig4) within … Ku and DNA-PKcs are sufficient
for LR complex formation, but other … For this purpose, we developed a three-color single-…

… have lower levels of mitochondrial DNA ligase IIIα, … NHEJ proteins including DNA PKcs
and DNA ligase IV/XRCC4. While these three core components are sufficient to join duplex DNA …

… DNA ligases III and IV (LIG3, LIG4) have long been credited … by 14 bp of duplex DNA were
found to be of sufficient length, … reaction reached saturation at low concentrations of the 3′-…

… NHEJ proteins directly or indirectly (Fig. 1). Direct ligation of the DNA ends is performed by
the XRCC4–DNA ligase 4 (… two DNA ends together suggests this enzyme is also sufficient to …

… synthesis, which generates sufficiently long de novo microhomologies … levels of core C-NHEJ
components such as Artemis and DNA ligase IV were downregulated while DNA ligase III …

… DNA-dependent protein kinase (DNA-PKcs), DNA ligase IV (… Third, we identified two
conserved loops in the middle HEAT … The resolution of the linker loop was not good enough to …

… end joining (NHEJ), which pairs DNA ends in a multiprotein … Ultimately, DNA ligase IV (LIG4),
which forms a constitutive … (80), supporting the idea that sufficient XLF tail length appears to …

… /80 (KU), XRCC4, DNA Ligase 4 (LIG4), XLF, and DNAPKcs … bridge DNA ends via interactions
with other proteins in the C-NHEJ … To test this hypothesis, we examined three sites in the …

… biochemical NHEJ system to compare the joining of free DNA … DNA ligase IV were purified
from High Five cells using three-… DSB DNA ends at an already accessible site is not sufficient …